29% Complete

The relationship between Glutathione and Peripheral neuropathy is somewhat weak. Glutathione ranks 71 of 915 Peripheral neuropathy treatments we have analyzed.

Peripheral neuropathy (PN) is damage or disease affecting nerves, which may impair sensation, movement, gland or organ function, or other aspects of health, depending on the type of nerve affected. Common causes include systemic diseases (such as diabetes or leprosy), vitamin deficiency, medication (e.g., chemotherapy), traumatic injury, excessive alcohol consumption, immune system disease, or infection, or it may be inherited (present from birth). In conventional medical usage, the word neuropathy (neuro-, "nervous system" and -pathy, "disease of") without modifier usually means peripheral neuropathy.1

Glutathione (GSH) is an important antioxidant in plants, animals, fungi and some bacteria and archaea, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides. It is a tripeptide with a gamma peptide linkage between the carboxyl group of the glutamate side-chain and the amine group of cysteine (which is attached by normal peptide linkage to a glycine).2

Researchers have concluded:

  • Releasing ROS to injure mitochondrion and endoplasmic reticulum maybe involved in bortezomib induced peripheral neuropathy. Although reduced glutathione can inhibit ROS release, it has no obviously reversal effect for peripheral neuropathy.3

Review all research »

Strength of evidence

Glutathione for Peripheral neuropathy ranks in the bottom 29% of condition-treatment relationships we analyzed.

Importantly, we found 2 studies that were randomized and controlled. Such studies are considered the most rigorous, and help to establish or disprove a cause-and-effect relationship between prospective treatments and conditions. So there may be some good evidence on which to make a decision about using Glutathione for Peripheral neuropathy.

Amount of research

The relationship between Peripheral neuropathy and Glutathione has been little researched. We found 136 research articles on the topic. This places the volume of research in the bottom 23% of condition-treatment relationships we have analyzed.

Research trends

Are researchers becoming more or less interested in Glutathione for Peripheral neuropathy? The pace of research appears to be increasing.

Registered clinical trials

We found 1 registered clinical trial investigating Glutathione for Peripheral neuropathy. It is not accepting participants.

Important caveat—help improve this information

Please note that our analysis is automated and imperfect. If you have personal insight, please help improve our analysis by rating this relationship and the research supporting it. And check back regularly; we last analyzed research for this relationship on September 06, 2014 @7:14PM, and are constantly updating our database and algorithms.

Other names
Glutathione for Peripheral neuropathy is also known as C10H17N3O6S for Arsenic neuritis, C10H17N3O6S for Autoimmune peripheral neuropathy, C10H17N3O6S for Deafferentation, C10H17N3O6S for Disorders of peripheral nervous system, C10H17N3O6S for Generalized.

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