The relationship between Vitamin B12 and Migraine is weak. Vitamin B12 ranks 138 of 510 Migraine treatments on our list.

Migraine is a chronic neurological disorder characterized by recurrent moderate to severe headaches often in association with a number of autonomic nervous system symptoms. The word derives from the Greek ἡμικρανία (hemikrania), "pain on one side of the head", from ἡμι- (hemi-), "half", and κρανίον (kranion), "skull".

Methylcobalamin (shown) is a form of Vitamin B12. Physically it resembles the other forms of vitamin B12, occurring as dark red crystals that freely form cherry-colored transparent solutions in water. Vitamin B12, vitamin B12 or vitamin B-12, also called cobalamin, is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the eight B vitamins. It is normally involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid metabolism and amino acid metabolism. Neither fungi, plants, nor animals are capable of producing vitamin B12. Only bacteria and archaea have the enzymes required for its synthesis, although many foods are a natural source of B12 because of bacterial symbiosis. The vitamin is the largest and most structurally complicated vitamin and can be produced industrially only through bacterial fermentation-synthesis.

Strength of evidence

Vitamin B12 for Migraine ranks in the bottom 17% of condition-treatment relationships we analyzed.

Importantly, we found 2 studies that were randomized and controlled. Such studies are considered the most rigorous, and help to establish or disprove a cause-and-effect relationship between prospective treatments and conditions. So there may be some good evidence on which to make a decision about using Vitamin B12 for Migraine.

Amount of research

The relationship between Migraine and Vitamin B12 has been modestly researched. We found 13 relevant research articles on the topic. This places the volume of research in the bottom 34% of condition-treatment relationships we analyzed.

Research trends

Are researchers becoming more or less interested in Vitamin B12 for Migraine? The pace of research appears to be decreasing:

Important caveat—help improve this information

Please note that our analysis is automated and imperfect. If you have personal insight, please help improve our analysis by rating this relationship and the research supporting it. And check back regularly; we last analyzed research for this relationship on Jun 29, 2014, and are constantly updating our database and algorithms.


Other names
Vitamin B12 for Migraine is also known as B12 with dermatosis for Amigrainous migraine, B12 with dermatosis for Anti-migraine, B12 with dermatosis for Basilar artery migraines, B12 with dermatosis for Basilar migraine, B12 with dermatosis for Basilar type migraine, B12 with dermatosis for Bickerstaff's migraine, B12 with dermatosis for Classical migraine, B12 with dermatosis for Common migraine, B12 with dermatosis for Facial migraine, B12 with dermatosis for Megrims, B12 with dermatosis for Migraine disorders, B12 with dermatosis for Migraine headache, B12 with dermatosis for Migraine headaches, B12 with dermatosis for Migraine journal, B12 with dermatosis for Migraine medication, B12 with dermatosis for Migraines, B12 with dermatosis for Migrane, B12 with dermatosis for Mígren, B12 with dermatosis for Mígreni, B12 with dermatosis for Optical migraine, Behepan for Amigrainous migraine, Behepan for Anti-migraine, Behepan for Basilar artery migraines, Behepan for Basilar migraine, 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